How I Treat
نویسندگان
چکیده
Isolated neutropenia without concomitant anemia or thrombocytopenia is a common clinical problem seen by primary care physicians and hematologists. The etiologies of neutropenia vary from transient suppression by self-limited viral illnesses to previously undetected congenital syndromes to serious systemic diseases. The clinical significance likewise ranges from amild laboratory abnormalitywith no detectable consequence to a severe disorder characterized by recurrent, life-threatening infections. Consequently, determining how extensive an evaluation is necessary and whether intervention is required can be challenging. This review discusses the evaluation and management of the neutropenic adult patient, as well as the pathophysiology of specific neutropenia syndromes. We begin by presenting the following 3 case vignettes, to which we will refer periodically during the review, to help illustrate aspects of the evaluation and management of neutropenic adults.
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